Presentation and Management of Primary Immune Thrombocytopenia in Children at the King Abdulaziz University Hospital, Jeddah, Saudi Arabia: A Retrospective Study

Authors

  • Nadia M. Fida King Abdulaziz University
  • Enas A. Hamed Assiut University
  • Soad M. Jaber King Abdulaziz University
  • Salwa A. Al Najjar King Abdulaziz University
  • Dhuha Al Amawi King Abdulaziz University
  • Fayza I. Al Siny King Abdulaziz University
  • Basma Alharthy King Abdulaziz University

DOI:

https://doi.org/10.4197/Med.28-1.2

Keywords:

Acute immune thrombocytopenia, Pediatric patients, Treatment management, International guidelines

Abstract

Immune thrombocytopenia is a common bleeding disease in pediatrics caused by low antiplatelet antibodies. Its treatment is controversial. This study aims to identify patterns of newly diagnosed immune thrombocytopenia presentation and treatment for children and adolescents admitted to the Pediatric Department at King Abdulaziz University Hospital over a three-year period. All patients who visited the pediatric clinic and were newly diagnosed with immune thrombocytopenia were enrolled. Data from patients’ files were collected and analyzed with respect to demographics, medical history, associated comorbidity, presentation, bleeding incidences (with scores), laboratory investigations, and therapies. Males outnumbered females (56.8% versus 43.2%). Of the 44 participants, 4 were found to have family history of Thrombocytopenia and 21 had previous viral infections. Comorbidities were reported in 7 patients and 5 were anemic. Bleeding degree was mild in 36 and moderate in 8 patients. Disease manifestations were mainly bruising and petechiae (n=30), bleeding gums (n=9), and epistaxis (n=9). Bone marrow aspirations were carried out in 25 patients. Otherwise, treatment modalities included 1) observation (n=5), 2) intravenous immunoglobulin (n=38), 3) corticosteroid (n=11), and 4) anti-D (n=1). Conclusion: the majority of children diagnosed with primary immune thrombocytopenia in the study received unnecessary intravenous immunoglobulin; following international guidelines in management of this disease would likely reduce admission rate, treatment costs, and patient exposure to adverse

Author Biographies

Nadia M. Fida, King Abdulaziz University

Department of Pediatrics, Faculty of Medicine
Professor of Pediatrics

 

Enas A. Hamed, Assiut University

Department of Physiology, Faculty of Medicine
Professor

Soad M. Jaber, King Abdulaziz University

Department of Pediatrics, Faculty of Medicine

Salwa A. Al Najjar, King Abdulaziz University

Department of Hematology, Faculty of Medicine

Dhuha Al Amawi, King Abdulaziz University

Department of Pediatrics, Faculty of Medicine

Fayza I. Al Siny, King Abdulaziz University

Department of Pediatrics, Faculty of Medicine

Basma Alharthy, King Abdulaziz University

Department of Pharmacology, Faculty of Medicine

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Published

2021-06-30

How to Cite

Fida, N. M., Hamed, E., Jaber, S., Al Najjar, S., Al Amawi, D., Al Siny, F., & Alharthy, B. (2021). Presentation and Management of Primary Immune Thrombocytopenia in Children at the King Abdulaziz University Hospital, Jeddah, Saudi Arabia: A Retrospective Study. Journal of King Abdulaziz University - Medical Sciences, 28(1), 1–9. https://doi.org/10.4197/Med.28-1.2

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Section

Articles