Paraganglioma of the Urinary Bladder

A Case Report




Paraganglioma, Urinary bladder, Pheochromocytoma, Transurethral resection of prostate


Urinary bladder paragangliomas are rare with a reported incidence of <1% of bladder tumors. We presented a case of a urinary bladder paraganglioma in a 26-year-old male who presented with a painless gross hematuria and hypertensive crisis occurring during his trans-urethral resection. Our diagnosis was based upon patient’s history, abdominal-pelvic computed tomography scan, which revealed a left-sided bladder wall mass 2.26 X 4.4 X 3.28 cm that was obstructing the left distal ureter and causing significant left severe hydroureter and hydronephrosis. Preoperative preparation was done with beta blocker and alpha blocker two weeks prior to surgery. The patient underwent an open surgical partial cystectomy, left nephroureterectomy and, complete external and internal iliac lymphadenectomy. Gross pathological examination of the mass revealed a 3x4.5x4 cm growth originating from the wall of the urinary bladder. Microscopic examination revealed nests invaded into muscularis propria of the urinary bladder, with no evidence of distant metastasis. Immunohistochemical studies showed positive tumor cells staining for chromogranin and synaptophysin while S100 highlighted the surrounding sustentacular cells. During the first 3-month post-operative follow-up period, the patient’s blood pressure was stabilized and the symptoms gradually subsided. Urinary bladder paragangliomas should be considered among the differential diagnosis of bladder tumors.

Author Biographies

Yara A. Fayoumi, King Abdulaziz University

Faculty of Medicine

Sarah A. Almagharbi, King Abdulaziz University

Faculty of Medicine

Taha A. Abdel-Meguid, King Abdulaziz University

Department of Urology, Faculty of Medicine, Professor

Department of Urology, Faculty of Medicine, Minia University, Egypt

Ahmed Abdelsalam, King Abdulaziz University

Department of Urology, Faculty of Medicine

Theodor Bilharz Research Institute, Cairo, Egypt

Najla M. Alghanmi, King Abdulaziz University Hospital, Jeddah

 Department of Pathology, Faculty of Medicine

Haneen Al-Maghrabi, King Faisal Specialist Hospital and Research Center, Jeddah

Department of Pathology

Raed A. Azhar, King Abdulaziz University Hospital, Jeddah

Department of Urology, Associate Professor

UC Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, USA




How to Cite

Fayoumi, Y. A., Almagharbi, S. A., Abdel-Meguid, T. A., Abdelsalam, A., Alghanmi, N. M., Al-Maghrabi, H., & Azhar, R. A. (2018). Paraganglioma of the Urinary Bladder: A Case Report. Journal of King Abdulaziz University - Medical Sciences, 25(2), 57–62.



Case Reports