Single Oral Dose of Fosfomycin Trometamol versus Ciprofloxacin for UTI prophylaxis in Invasive Urodynamics: A Prospective Randomized Double Blind Clinical Trial

Authors

  • Hisham A. Mosli King Abdulaziz University
  • Hasan M.A. Farsi King Abdulaziz University
  • Taha A. Abdulmagied King Abdulaziz University
  • Abdulmalik M.S. Tayib King Abdulaziz University
  • Ahmed J. Al-Sayyad King Abdulaziz University
  • M. Mamdoh Rezk King Abdulaziz University
  • Adel K. Altwarigi King Abdulaziz University
  • M. Hani Abdulwahab King Abdulaziz University

DOI:

https://doi.org/10.4197/med.20-2.1

Keywords:

Antibiotic prophylaxis; UTI; Urodynamics; Fosfomycin trometamol; Ciprofloxacin

Abstract

The aim is to test the efficacy of a single oral dose of fosfomycin trometamol in preventing urinary tract infection as compared to ciprofloxacin in patients undergoing invasive urodynamics studies. Patients were randomized into 2 groups: A and B. Group A: a random group of patients undergoing urodynamics studies received a single pre-procedure dose of fosfomycin trometamol 3 gms orally 3 hours before the study. Group B: a random group of patients received a single pre-procedure dose of 500 mg ciprofloxacin 3 hours before the study. A total of 65 patients enrolled in the study (45 females and 20 males); the age range from 10 to 75 years with a mean of 50.32 ± 13.5. There were 39 patients in group A and 26 patients in group B. The post-procedure urine analysis showed increased presence of WBCs in Group A (fosfomycin trometamol) compared to group B (ciprofloxacin). Post-procedure, the negative urine cultures were reduced from 59% to 20.5% for group A and comparably from 57.7% to 23.1% in group B. A single dose of both fosfomycin trometamol and ciprofloxacin were equally in-effective in the prophylaxis against UTI in patients undergoing urodynamics studies.  

Author Biographies

Hisham A. Mosli, King Abdulaziz University

Department of Urology  

Hasan M.A. Farsi, King Abdulaziz University

Department of Urology

Taha A. Abdulmagied, King Abdulaziz University

Department of Urology

Abdulmalik M.S. Tayib, King Abdulaziz University

Department of Urology

Ahmed J. Al-Sayyad, King Abdulaziz University

Department of Urology

M. Mamdoh Rezk, King Abdulaziz University

Department of Urology

Adel K. Altwarigi, King Abdulaziz University

Department of Urology

M. Hani Abdulwahab, King Abdulaziz University

Department of Urology

Published

2013-04-01

How to Cite

Mosli, H. A., Farsi, H. M., Abdulmagied, T. A., Tayib, A. M., Al-Sayyad, A. J., Rezk, M. M., Altwarigi, A. K., & Abdulwahab, M. H. (2013). Single Oral Dose of Fosfomycin Trometamol versus Ciprofloxacin for UTI prophylaxis in Invasive Urodynamics: A Prospective Randomized Double Blind Clinical Trial. Journal of King Abdulaziz University - Medical Sciences, 20(2), 3-12. https://doi.org/10.4197/med.20-2.1

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