The Effect of PM 701 on Mice Leukemic Cells: I - Tissue Culture Study of L1210 (<em>In Vitro</em>) II - <em>In Vivo</em> Study on Mice
Apoptosis was originally reported in 1972 and was described as programmed cell death. This process is very common in normal tissues with high proliferate activity such as bone marrow and has also been implicated in the progression of a number of diseases, including AIDS, cancer and autoimmune pathologies. This study was conducted in two phases. The first phase used tissue culture of leukemia cells from mice in studying the effectiveness of agent (PM 701) on the behavior of these types of cells. This new agent, PM 701, proved to induce apoptosis of the cancer cells without affecting normal cells; the results showed that all tested concentrations of (PM 701) inhibited the growth of the cancer cells (L1210), with maximum effect at medium concentration. This finding is similar to our previous result in the use of (PM 701) as selective killing of tissue cultured lung cancer cells (A549). The second phase of this study was in vivo testing of the effect of (PM 701) in treating MFI mice that were infected with L1210 cells; the result of in vivo testing was satisfactory as in vitro effect at the tissue culture level.
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