Anti-Cyclic Citrullinated Peptide and Rheumatoid Factor (Prevalence and Association) in Saudi Rheumatoid Arthritis Patients

Keywords: Saudi Arabia, Anti-cyclic citrullinated peptides antibodies, Rheumatoid arthritis, Rheumatoid factor, Clinical association

Abstract

To assess the prevalence and association of anti-cyclic citrullinated peptides and rheumatoid factor in Saudi rheumatoid arthritis patients.
Over three years (February 2011 - February 2014). Demographic and clinical features, drugs, rheumatoid factor-positivity, and anti-cyclic citrullinated peptides-positivity were recorded for 205 Saudi rheumatoid arthritis patients (185 females; mean age was 45 years and mean disease duration was 5 years). Anti-cyclic citrullinated peptides and rheumatoid factor were assessed in serum. Disease activity scores for 28 joints was used. There were 36% rheumatoid factor+ve and 45% anti-cyclic citrullinated peptides+ve. 21.5% of the rheumatoid factor-ve subjects were anti-cyclic citrullinated peptides+ve. 13.3% of the rheumatoid factor positive patients were anti-cyclic citrullinated peptides-ve and 86.7% were anti-cyclic citrullinated peptides+ve. Significant association (P < 0.05) of anti-cyclic citrullinated peptides-positivity and rheumatoid factor-positivity with each other, and with gender, use of disease–modifying antirheumatic drugs, hydroxychloroquine and methotrexate. No direct impact of anti-cyclic citrullinated peptides status on the disease activity scores for 28 joints or its constituents (P > 0.5); nevertheless, anti-cyclic citrullinated peptides positive patients appear to represent a greater need for combination disease modifying drugs. 

Author Biographies

Mohammad-Ayman A. Safi, King Abdulaziz University

Department of Medical Microbiology and Parasitology, Faculty of Medicine

Dhiya T. Houssien, Dr. Dhiya Centre for Rheumatism & Physiotherapy and Acupuncture

Department of Rheumatism, Physiotherapy and Acupuncture

Published
2018-12-31
How to Cite
Safi, M.-A. A., & Houssien, D. T. (2018). Anti-Cyclic Citrullinated Peptide and Rheumatoid Factor (Prevalence and Association) in Saudi Rheumatoid Arthritis Patients. Journal of King Abdulaziz University - Medical Sciences, 25(2), 1-10. https://doi.org/10.4197/Med.25-2.1
Section
Articles